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PRSS57 Q6UWY2

丝氨酸蛋白酶57 (EC 3.4.21.-) (中性粒细胞丝氨酸蛋白酶4) (NSP4) (丝氨酸蛋白酶1样蛋白1)

蛋白质信息 (UniProt)

丝氨酸蛋白酶57 (EC 3.4.21.-) (中性粒细胞丝氨酸蛋白酶4) (NSP4) (丝氨酸蛋白酶1样蛋白1)

Q6UWY2

功能描述

丝氨酸蛋白酶,优先在Arg残基后切割 (PubMed:22474388, PubMed:23904161, PubMed:25156428)。也能在瓜氨酸(去亚胺基精氨酸)和甲基精氨酸残基后切割 (PubMed:25156428)。 {ECO:0000269|PubMed:22474388, ECO:0000269|PubMed:23904161, ECO:0000269|PubMed:25156428}。

组织特异性

Detected in peripheral blood neutrophil granulocytes, but not in other types of leukocytes. Detected in neutrophils and neutrophil precursors in bone marrow (at protein level) (PubMed:22474388, PubMed:23904161). Detected in myeloblasts and promyelocytes in bone marrow (PubMed:23904161).

亚细胞定位

Cytoplasmic granule lumen

关键词

3D-structure Disulfide bond Glycoprotein Heparin-binding Hydrolase Protease Proteomics identification Reference proteome Secreted Serine protease