PRR7 Q8TB68

富含脯氨酸蛋白 7 (突触富含脯氨酸膜蛋白)

功能描述

作为突触至细胞核的信使，以依赖JUN的方式促进神经元中NMDA受体介导的兴奋性毒性 (By similarity)。抑制泛素化介导的降解，促进转录因子JUN的磷酸化和转录活性 (PubMed:27458189)。可能在T细胞受体信号传导的调节中发挥冗余作用 (PubMed:21460222)。可能促进T细胞凋亡 (PubMed:21460222)。 {ECO:0000250|UniProtKB:P0C6T3, ECO:0000250|UniProtKB:Q3V0I2, ECO:0000269|PubMed:21460222, ECO:0000269|PubMed:27458189}。

组织特异性

Strongly expressed in brain tissue including the hippocampus, and moderately expressed in esophagus, trachea, lung, ovary, cervix, prostate, testes, thyroid, thymus, lymph nodes and peripheral blood lymphocytes.

亚细胞定位

Cell membrane