PRAP1 Q96NZ9

富含脯氨酸酸性蛋白 1 (附睾组织蛋白 Li 178) (子宫特异性富含脯氨酸酸性蛋白)

功能描述

脂质结合蛋白，通过促进MTTP介导的脂质转移（主要是甘油三酯和磷脂）以及MTTP介导的apoB脂蛋白组装和分泌来促进脂质吸收 (By similarity)。保护胃肠道上皮细胞免受辐射诱导的细胞凋亡 (By similarity)。可能在维持上皮细胞正常生长稳态中发挥重要作用 (PubMed:14583459)。参与DNA损伤后依赖p53/TP53的细胞存活 (PubMed:23235459)。可能在肝细胞癌中下调MAD1L1的表达，并在有丝分裂纺锤体组装检查点中发挥抑制作用 (PubMed:24374861)。 {ECO:0000250|UniProtKB:Q80XD8, ECO:0000269|PubMed:14583459, ECO:0000269|PubMed:23235459, ECO:0000269|PubMed:24374861}。

组织特异性

Highly expressed in the intestinal epithelial cells (at protein level) (PubMed:32629119). Abundantly expressed in the epithelial cells of the liver, kidney and cervix. Significantly down-regulated in hepatocellular carcinoma and right colon adenocarcinoma compared with the respective adjacent normal tissues. Expressed in epididymis (at protein level).

亚细胞定位

Secreted