PPIL2 Q13356

RING型E3泛素蛋白连接酶PPIL2 (EC 2.3.2.27) (CYC4) (亲环蛋白-60) (亲环蛋白样蛋白Cyp-60) (Cyp60) (hCyP-60) (推定无活性肽酰脯氨酰顺反异构酶样2) (PPIase) (旋转酶PPIL2)

功能描述

具有泛素-蛋白连接酶活性，作为E3泛素蛋白连接酶或泛素-泛素连接酶促进底物上泛素链的延伸。通过介导蛋白质的'Lys-48'连接的多泛素化，可靶向它们进行蛋白酶体降解 (PubMed:11435423)。也可能作为分子伴侣发挥作用，例如在BSG/Basigin转运至细胞膜的过程中起作用 (PubMed:15946952)。可能是无活性的PPIase，没有肽基脯氨酰顺反异构酶活性 (PubMed:20676357)。作为次要剪接体的组分，参与pre-mRNAs中U12型内含子的剪接 (Probable)。 {ECO:0000269|PubMed:11435423, ECO:0000269|PubMed:15946952, ECO:0000269|PubMed:20676357, ECO:0000305|PubMed:33509932}。

组织特异性

Highest expression in thymus, pancreas and testis. Also detected in heart, placenta, lung, liver, skeletal muscle, kidney, spleen, prostate, ovary, small intestine and colon. Poorly detected in brain and leukocytes. Strong protein expression in lymph node (cortical, paracortical and medullar regions), thyroid (follicular epithelial cells), testis (developing spermatozoa), stomach (cells lining the gastric pit), pancreas, kidney (proximal and distal-tubule cells and collecting duct cells but not in glomeruli), endometrium and colon (goblet cells). Moderate protein expression in spleen, prostate (epithelium and squamous cell carcinomas), placenta and adrenal gland. Weak protein expression in liver, heart, breast, ovary, and lung. No protein expression in brain and bladder. High protein expression in most lymphomas and melanomas.

亚细胞定位

Nucleus