过氧化物酶体增殖物激活受体γ辅激活因子1-α (PGC-1-alpha) (PPAR-γ辅激活因子1-α) (PPARGC-1-alpha) (配体效应调节因子6)
过氧化物酶体增殖物激活受体γ辅激活因子1-α (PGC-1-alpha) (PPAR-γ辅激活因子1-α) (PPARGC-1-alpha) (配体效应调节因子6)
Q9UBK2功能描述
Steroid receptors和nuclear receptors的转录共激活因子 (PubMed:10713165, PubMed:20005308, PubMed:21376232, PubMed:28363985, PubMed:32433991). 极大地增加了PPARG和thyroid hormone receptor在解偶联protein启动子上的转录活性 (PubMed:10713165, PubMed:20005308, PubMed:21376232). 能够调节关键的线粒体genes，这些genes有助于适应性产热程序 (PubMed:10713165, PubMed:20005308, PubMed:21376232). 通过协调参与葡萄糖和脂肪酸代谢的一系列广泛genes的表达，在响应膳食可用性的代谢重编程中发挥重要作用 (PubMed:10713165, PubMed:20005308, PubMed:21376232). 作为糖异生的关键调节因子：通过增加糖异生enzymes的表达来刺激肝脏糖异生，并与FOXO1协同作用促进空腹糖异生程序 (PubMed:16753578, PubMed:23142079). 以ESRRA依赖的方式诱导骨骼肌中PERM1的表达 (PubMed:23836911). 也参与生物节律和能量代谢的整合 (By similarity). 为clock genes（如BMAL1和NR1D1）以及代谢genes（如PDK4和PEPCK）的振荡表达所必需，通过RORA和RORC的共激活实现 (By similarity). {ECO:0000250|UniProtKB:O70343, ECO:0000269|PubMed:10713165, ECO:0000269|PubMed:16753578, ECO:0000269|PubMed:20005308, ECO:0000269|PubMed:21376232, ECO:0000269|PubMed:23142079, ECO:0000269|PubMed:23836911, ECO:0000269|PubMed:28363985, ECO:0000269|PubMed:32433991}.
组织特异性
Heart, skeletal muscle, liver and kidney. Expressed at lower levels in brain and pancreas and at very low levels in the intestine and white adipose tissue. In skeletal muscle, levels were lower in obese than in lean subjects and fasting induced a 2-fold increase in levels in the skeletal muscle in obese subjects.
亚细胞定位
[Isoform 1]: Nucleus
关键词