骨膜蛋白 (PN) (成骨细胞特异性因子2) (OSF-2)
骨膜蛋白 (PN) (成骨细胞特异性因子2) (OSF-2)
Q15063功能描述
诱导细胞附着和铺展，并在细胞粘附中发挥作用 (PubMed:12235007)。增强BMP1在结缔组织纤连蛋白基质中的整合，以及随后的赖氨酰氧化酶LOX的蛋白水解激活 (By similarity)。 {ECO:0000250|UniProtKB:Q62009, ECO:0000269|PubMed:12235007}。
组织特异性
Widely expressed with highest levels in aorta, stomach, lower gastrointestinal tract, placenta, uterus, thyroid tissue and breast. Expressed in the kidney (PubMed:21763681). Expressed in the lung (PubMed:22079858). Up-regulated in epithelial ovarian tumors. Not expressed in normal ovaries. Also highly expressed at the tumor periphery of lung carcinoma tissue but not within the tumor. Overexpressed in breast cancers.
亚细胞定位
Golgi apparatus
关键词