POLE3 Q9NRF9

DNA聚合酶ε亚基3 (砷反式激活蛋白) (AsTP) (染色质可及性复合物17 kDa蛋白) (CHRAC-17) (HuCHRAC17) (DNA聚合酶II亚基3) (DNA聚合酶ε亚基p17)

蛋白质信息 (UniProt)

DNA聚合酶ε亚基3 (砷反式激活蛋白) (AsTP) (染色质可及性复合物17 kDa蛋白) (CHRAC-17) (HuCHRAC17) (DNA聚合酶II亚基3) (DNA聚合酶ε亚基p17)

Q9NRF9

功能描述

DNA聚合酶epsilon复合物的辅助成分 (PubMed:10801849)。参与DNA修复和染色体DNA复制 (By similarity)。与CHRAC1形成复合物并结合裸露DNA，随后在ISWI/SNF2H和ACF1的核小体重塑活性协助下将其整合到染色质中 (PubMed:10801849)。不增强ACF-5 ISWI染色质重塑复合物的核小体滑动活性 (PubMed:14759371)。 {ECO:0000250|UniProtKB:Q04603, ECO:0000269|PubMed:10801849, ECO:0000269|PubMed:14759371}。

组织特异性

Expressed in heart, brain, placenta, lung, liver, skeletal muscle, kidney and pancreas.

亚细胞定位

Nucleus

关键词

Acetylation Coiled coil Direct protein sequencing DNA-binding Nucleus Phosphoprotein Proteomics identification Reference proteome

外部链接

UniProt: Q9NRF9

NCBI Gene

GeneCards