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PODXL2 Q9NZ53

类足萼蛋白2 (Endoglycan)

蛋白质信息 (UniProt)

类足萼蛋白2 (Endoglycan)

Q9NZ53

功能描述

作为血管选择素的配体。通过与E-、P-和L-选择素的高亲和力二价阳离子依赖性相互作用,介导白细胞在血管表面的快速滚动。 {ECO:0000269|PubMed:18606703}。

组织特异性

Expressed in T-cells, B-cells and monocytes. Expression is higher on memory and germinal center cells than on naive B-cells (at protein level). Highly expressed in brain. Moderately expressed in pancreas, kidney and lymphoid node. Weakly expressed in liver. Detected in both endothelial cells and CD34+ bone marrow cells.

亚细胞定位

Membrane

关键词

Alternative splicing Cell adhesion Direct protein sequencing Disulfide bond Glycoprotein Membrane Phosphoprotein Proteoglycan Proteomics identification Reference proteome