PNP P00491

嘌呤核苷磷酸化酶 (PNP) (EC 2.4.2.1) (肌苷磷酸化酶) (肌苷-鸟苷磷酸化酶)

蛋白质信息 (UniProt)

嘌呤核苷磷酸化酶 (PNP) (EC 2.4.2.1) (肌苷磷酸化酶) (肌苷-鸟苷磷酸化酶)

P00491

功能描述

催化beta-(脱氧)核糖核苷分子中N-糖苷键的磷酸解断裂，形成相应的游离嘌呤碱基和戊糖-1-磷酸 (PubMed:23438750, PubMed:3029074, PubMed:9305964)。优先作用于6-氧嘌呤核苷，包括肌苷和鸟苷 (PubMed:9305964)。 {ECO:0000269|PubMed:23438750, ECO:0000269|PubMed:3029074, ECO:0000269|PubMed:9305964}。

组织特异性

Expressed in red blood cells; overexpressed in red blood cells (cytoplasm) of patients with hereditary non-spherocytic hemolytic anemia of unknown etiology.

亚细胞定位

Cytoplasm, cytosol

关键词

3D-structure Acetylation Cytoplasm Direct protein sequencing Disease variant Glycosyltransferase Phosphoprotein Proteomics identification Purine salvage Reference proteome

外部链接

UniProt: P00491

NCBI Gene

GeneCards