PLCL1 Q15111

无活性磷脂酶C样蛋白1 (PLC-L1) (肺癌缺失磷脂酶C) (磷脂酶C相关但催化无活性蛋白) (PRIP)

功能描述

参与基于肌醇磷脂的细胞内信号级联反应。对磷脂酰肌醇4,5-二磷酸和磷脂酰肌醇无PLC活性。GABA A受体磷酸化依赖性内吞过程的组分 (By similarity)。调节受体的周转，从而有助于维持GABA介导的突触抑制。其异常表达可能促进肺癌的发生和进展。作为PPP1C的抑制剂。 {ECO:0000250, ECO:0000269|PubMed:17254016}。

组织特异性

Expressed in a variety of fetal and adult organs including brain, lung and kidney. Its expression was greatly reduced in small and non-small cell lung carcinoma. Isoform 1 is predominantly expressed in brain.

亚细胞定位

Cytoplasm