PLA2G2F Q9BZM2

IIF族分泌型磷脂酶A2 (GIIF sPLA2) (sPLA2-IIF) (EC 3.1.1.4) (磷脂酰胆碱2-酰基水解酶2F)

功能描述

分泌型钙依赖性磷脂酶A2，主要靶向细胞外磷脂。水解连接在磷脂sn-2位点的脂肪酰基酯键（磷脂酶A2活性），催化效率按以下顺序递减：磷脂酰甘油 > 磷脂酰乙醇胺 > 磷脂酰胆碱 > 磷脂酰丝氨酸 (PubMed:11112443)。可能在炎症条件下通过为下游环加氧酶和脂加氧酶提供花生四烯酸，在脂质介质产生中发挥作用 (By similarity)。 {ECO:0000250|UniProtKB:Q9QZT4, ECO:0000269|PubMed:11112443}。

组织特异性

Expressed at high levels in placenta, testis, thymus and at lower levels in heart, kidney, liver and prostate (PubMed:11112443). Highly expressed in rheumatoid arthritic tissues, including synovial lining cells in the intima, capillary endothelial cells and plasma cells (PubMed:11877435).

亚细胞定位

[Isoform 1]: Secreted