肽酰脯氨酰顺反异构酶NIMA相互作用蛋白4 (EC 5.2.1.8) (细小蛋白-14) (Par14) (hPar14) (细小蛋白-17) (Par17) (hPar17) (肽酰脯氨酰顺反异构酶Pin4) (PPIase Pin4) (肽酰脯氨酰顺/反异构酶EPVH) (hEPVH) (旋转酶Pin4)
肽酰脯氨酰顺反异构酶NIMA相互作用蛋白4 (EC 5.2.1.8) (细小蛋白-14) (Par14) (hPar14) (细小蛋白-17) (Par17) (hPar17) (肽酰脯氨酰顺反异构酶Pin4) (PPIase Pin4) (肽酰脯氨酰顺/反异构酶EPVH) (hEPVH) (旋转酶Pin4)
Q9Y237功能描述
Isoform 1 作为一种核糖体RNA加工因子参与核糖体生物合成。结合双链DNA的紧密弯曲AT富集区。 {ECO:0000269|PubMed:19369196}.; FUNCTION: Isoform 2 结合双链DNA。 {ECO:0000269|PubMed:19369196}.
组织特异性
Isoform 2 is much more stable than isoform 1 (at protein level). Ubiquitous. Isoform 1 and isoform 2 are expressed in kidney, liver, blood vessel, brain, mammary gland, skeletal muscle, small intestine and submandibularis. Isoform 1 transcripts are much more abundant than isoform 2 in each tissue analyzed.
亚细胞定位
[Isoform 1]: Nucleus, nucleolus. Cytoplasm, cytoskeleton, spindle. Cytoplasm. Note=Colocalizes in the nucleolus during interphase and on the spindle apparatus during mitosis with NPM1.; SUBCELLULAR LOCATION: [Isoform 2]: Mitochondrion. Mitochondrion matrix. Note=Imported in a time- and membrane potential-dependent manner to the mitochondrial matrix, but without concomitant processing of the protein. Directed to mitochondria by a novel N-terminal domain that functions as a non-cleavable mitochondrial targeting peptide.
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