PHLPP2 Q6ZVD8

PH域富含亮氨酸重复序列蛋白磷酸酶2 (EC 3.1.3.16) (PH域富含亮氨酸重复序列蛋白磷酸酶样) (PHLPP样)

功能描述

参与调节Akt和PKC信号通路的蛋白磷酸酶。介导AGC Ser/Thr蛋白激酶家族成员C末端结构域疏水基序的去磷酸化；特异性作用于AKT1的'Ser-473'，PRKCB亚型beta-II的'Ser-660'以及PRKCA的'Ser-657'。Akt通过主要改变调节促凋亡和抗凋亡基因的转录因子功能的级联反应，调节细胞存活与凋亡之间的平衡。Akt的'Ser-473'去磷酸化触发凋亡并减少细胞增殖。亦控制AKT3的磷酸化。将STK4的'Thr-387'去磷酸化，导致STK4激活和凋亡 (PubMed:20513427)。将RPS6KB1去磷酸化并参与帽依赖性翻译的调节 (PubMed:21986499)。抑制癌细胞增殖并可能作为肿瘤抑制因子发挥作用。PRKCA和PRKCB的去磷酸化导致其不稳定和降解。将RAF1去磷酸化从而抑制其激酶活性 (PubMed:24530606)。 {ECO:0000269|PubMed:17386267, ECO:0000269|PubMed:18162466, ECO:0000269|PubMed:19079341, ECO:0000269|PubMed:20513427, ECO:0000269|PubMed:21986499, ECO:0000269|PubMed:24530606}。

组织特异性

In colorectal cancer tissue, expression is highest in the surface epithelium of normal colonic mucosa adjacent to the cancer tissue but is largely excluded from the crypt bases. Expression is lost or significantly decreased in 80% of tested tumors (at protein level).

亚细胞定位

Cytoplasm. Membrane; Peripheral membrane protein. Nucleus. Note=In colorectal cancer tissue, expression is concentrated in the cytoplasm and nucleus.