Pleckstrin同源样结构域家族A成员2 (Beckwith-Wiedemann综合征染色体区域1候选基因C蛋白) (胎盘和肝脏印记蛋白) (肿瘤抑制STF cDNA 3蛋白) (肿瘤抑制亚染色体转移片段候选基因3蛋白) (p17-Beckwith-Wiedemann区域1 C) (p17-BWR1C)
Pleckstrin同源样结构域家族A成员2 (Beckwith-Wiedemann综合征染色体区域1候选基因C蛋白) (胎盘和肝脏印记蛋白) (肿瘤抑制STF cDNA 3蛋白) (肿瘤抑制亚染色体转移片段候选基因3蛋白) (p17-Beckwith-Wiedemann区域1 C) (p17-BWR1C)
Q53GA4功能描述
在调节胎盘生长中发挥作用。可能通过其PH结构域起作用，该结构域与其他含PH结构域的蛋白竞争，从而阻止它们与膜脂结合 (By similarity)。 {ECO:0000250}。
组织特异性
Expressed in placenta and adult prostate gland. In placenta, it is present in all cells of the villous cytotrophoblast. The protein is absent in cells from hydatidiform moles. Hydatidiform mole is a gestation characterized by abnormal development of both fetus and trophoblast. The majority of hydatidiform moles are associated with an excess of paternal to maternal genomes and are likely to result from the abnormal expression of imprinted genes (at protein level). Expressed at low levels in adult liver and lung, and fetal liver. Expressed in adult brain and neuroblastoma, medullablastoma and glioblastoma cell lines.
亚细胞定位
Cytoplasm
关键词