PHF19 Q5T6S3

PHD指蛋白19 (类多梳蛋白3) (hPCL3)

功能描述

多梳群 (PcG) 蛋白，特异性结合 'Lys-36' 处三甲基化的组蛋白 H3 (H3K36me3) 并招募 PRC2 复合物，从而增强 PRC2 的 H3K27me3 甲基化活性 (PubMed:15563832, PubMed:18691976, PubMed:23104054, PubMed:23160351, PubMed:23228662, PubMed:23273982, PubMed:29499137, PubMed:31959557)。可能参与胚胎干细胞从活跃状态向抑制状态的转变：通过结合 H3K36me3（一种转录激活标记）并招募 H3K36me3 组蛋白去甲基化酶 RIOX1 或 KDM2B，导致 H3K36 去甲基化并招募介导 H3K27me3 甲基化的 PRC2 复合物，随后发生从头沉默 (PubMed:23160351)。招募 PRC2 复合物至 CpG 岛并促进胚胎干细胞自我更新。亦结合 'Lys-36' 处二甲基化的组蛋白 H3 (H3K36me2) (PubMed:23104054)。Isoform 1 和 isoform 2 抑制 HSV-tk 启动子的转录 (PubMed:15563832)。 {ECO:0000269|PubMed:15563832, ECO:0000269|PubMed:18691976, ECO:0000269|PubMed:23104054, ECO:0000269|PubMed:23160351, ECO:0000269|PubMed:23228662, ECO:0000269|PubMed:23273982, ECO:0000269|PubMed:29499137, ECO:0000269|PubMed:31959557}。

组织特异性

Isoform 1 is expressed in thymus, heart, lung and kidney. Isoform 2 is predominantly expressed in placenta, skeletal muscle and kidney, whereas isoform 1 is predominantly expressed in liver and peripheral blood leukocytes. Overexpressed in many types of cancers, including colon, skin, lung, rectal, cervical, uterus, liver cancers, in cell lines derived from different stages of melanoma and in glioma cell lines.

亚细胞定位

Nucleus