PGK2 P07205

磷酸甘油酸激酶2 (EC 2.7.2.3) (磷酸甘油酸激酶，睾丸特异性)

蛋白质信息 (UniProt)

磷酸甘油酸激酶2 (EC 2.7.2.3) (磷酸甘油酸激酶，睾丸特异性)

P07205

功能描述

催化1,3-二磷酸甘油酸可逆转化为3-磷酸甘油酸，并在糖酵解和糖异生中发挥作用 (By similarity)。对精子运动能力和雄性生育能力至关重要 (PubMed:26677959)。精子发生的完成不需要此酶 (By similarity)。 {ECO:0000250|UniProtKB:P09041, ECO:0000269|PubMed:26677959}。

组织特异性

Mainly found in round spermatids. Localized on the principle piece in the sperm (at protein level). Testis-specific. Expression significantly decreased in the testis of elderly men.

亚细胞定位

Cytoplasm

关键词

Acetylation ATP-binding Cytoplasm Glycolysis Kinase Magnesium Metal-binding Nucleotide-binding Phosphoprotein Proteomics identification

外部链接

UniProt: P07205

NCBI Gene

GeneCards