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PFN2 P35080

profilin-2 (Profilin II)

蛋白质信息 (UniProt)

profilin-2 (Profilin II)

P35080

功能描述

结合肌动蛋白并影响细胞骨架的结构。在高浓度下，profilin抑制肌动蛋白的聚合，而在低浓度下则促进聚合。通过结合PIP2，抑制IP3和DG的形成。

组织特异性

Highly expressed in brain, skeletal muscle and kidney and less strongly in heart, placenta, lung and liver.

亚细胞定位

Cytoplasm, cytoskeleton.

关键词

3D-structure Acetylation Actin-binding Alternative splicing Cytoplasm Cytoskeleton Direct protein sequencing Proteomics identification Reference proteome

外部链接

UniProt: P35080
NCBI Gene