E3泛素蛋白连接蛋白pellino同源蛋白3 (Pellino-3) (EC 2.3.2.27)
E3泛素蛋白连接蛋白pellino同源蛋白3 (Pellino-3) (EC 2.3.2.27)
Q8N2H9功能描述
E3 ubiquitin ligase，催化ubiquitin部分共价附着到底物protein上 (PubMed:12874243, PubMed:17675297)。通过与包含IRAK kinase和TRAF6的复合体相互作用，参与TLR和IL-1信号通路 (PubMed:12874243)。介导IRAK1的'Lys-63'连接的多ubiquitination (PubMed:12874243)。能激活AP1/JUN和ELK1 (PubMed:12874243)。作为先天免疫调节因子，通过介导NOD1和NOD2下游RIPK2的'Lys-63'连接的多ubiquitination发挥作用，从而将RIPK2转化为下游效应子的支架protein，最终导致NF-kappa-B和MAP kinase信号的激活 (By similarity)。与XIAP平行催化RIPK2的'Lys-63'连接的多ubiquitination (By similarity)。 {ECO:0000250|UniProtKB:Q8BXR6, ECO:0000269|PubMed:12874243, ECO:0000269|PubMed:17675297}。
组织特异性
Highly expressed in brain, heart and testis, and at lower level in kidney, liver, lung, placenta, small intestine, spleen and stomach. Isoform 1 is not expressed in lung.
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