PECAM1 P16284

血小板内皮细胞粘附分子 (PECAM-1) (EndoCAM) (GPIIA') (PECA1) (CD抗原 CD31)

功能描述

细胞粘附分子，在大多数炎症条件下是白细胞跨内皮迁移（TEM）所必需的 (PubMed:17580308, PubMed:19342684)。Tyr-690 在 TEM 中起关键作用，是 PECAM1 在侧边界循环区室（LBRC）间高效运输所必需的，并且对于 LBRC 膜靶向包裹迁移的白细胞也至关重要 (PubMed:19342684)。反式同嗜性相互作用可能通过细胞连接在内皮细胞-细胞粘附中发挥作用 (PubMed:27958302)。与 CD177 的异嗜性相互作用在嗜中性粒细胞的跨内皮迁移中发挥作用 (PubMed:17580308)。PECAM1 的同嗜性连接通过传递分离信号，阻止巨噬细胞介导的对邻近存活白细胞的吞噬作用 (PubMed:12110892)。通过将凋亡白细胞系留于吞噬细胞，促进巨噬细胞介导的对凋亡白细胞的吞噬作用；PECAM1 介导的分离信号在凋亡白细胞中似乎失效 (PubMed:12110892)。调节缓激肽受体 BDKRB2 的激活 (PubMed:18672896)。调节内皮细胞中缓激肽和高渗休克诱导的 ERK1/2 激活 (PubMed:18672896)。诱导动脉粥样硬化易感性 (By similarity)。 {ECO:0000250|UniProtKB:Q08481, ECO:0000269|PubMed:12110892, ECO:0000269|PubMed:17580308, ECO:0000269|PubMed:18672896, ECO:0000269|PubMed:19342684, ECO:0000269|PubMed:27958302}.; FUNCTION: [Isoform Delta15]: 不保护细胞免于凋亡。 {ECO:0000269|PubMed:18388311}.

组织特异性

Expressed on platelets and leukocytes and is primarily concentrated at the borders between endothelial cells (PubMed:18388311, PubMed:21464369). Expressed in human umbilical vein endothelial cells (HUVECs) (at protein level) (PubMed:17580308, PubMed:19342684). Expressed on neutrophils (at protein level) (PubMed:17580308). Isoform Long predominates in all tissues examined (PubMed:12433657). Isoform Delta12 is detected only in trachea (PubMed:12433657). Isoform Delta14-15 is only detected in lung (PubMed:12433657). Isoform Delta14 is detected in all tissues examined with the strongest expression in heart (PubMed:12433657). Isoform Delta15 is expressed in brain, testis, ovary, cell surface of platelets, human umbilical vein endothelial cells (HUVECs), Jurkat T-cell leukemia, human erythroleukemia (HEL) and U-937 histiocytic lymphoma cell lines (at protein level) (PubMed:12433657, PubMed:18388311).

亚细胞定位

Cell membrane