PDE9A O76083

高亲和力cGMP特异性3',5'-环磷酸二酯酶9A (EC 3.1.4.35)

功能描述

特异性水解第二信使cGMP，这是许多重要生理过程的关键调节因子。具有高度特异性：与cyclic nucleotide phosphodiesterase家族的其他成员相比，对cGMP具有最高的亲和力和选择性 (PubMed:18757755, PubMed:21483814, PubMed:9624146)。在心脏中特异性调节利钠肽依赖的cGMP信号传导，作为心肌细胞和肌肉中心脏肥大的调节因子。不调节心脏中一氧化氮依赖的cGMP (PubMed:25799991)。需要额外的实验来证实其水解利钠肽依赖的cGMP的能力是心脏特有的还是该蛋白的一般特征 (Probable)。在脑中，参与认知功能，如学习和长期记忆 (By similarity)。 {ECO:0000250|UniProtKB:Q8QZV1, ECO:0000269|PubMed:18757755, ECO:0000269|PubMed:21483814, ECO:0000269|PubMed:25799991, ECO:0000269|PubMed:9624146, ECO:0000305}。

组织特异性

Expressed in all tissues examined (testis, brain, small intestine, skeletal muscle, heart, lung, thymus, spleen, placenta, kidney, liver, pancreas, ovary and prostate) except blood (PubMed:9624146). Highest levels in brain, heart, kidney, spleen, prostate and colon. Isoform PDE9A12 is found in prostate (PubMed:12565835). In brain, present in the cortex, cerebellum, and subiculum (at protein level) (PubMed:22328573). In heart, primarily localizes to myocytes (PubMed:25799991).

亚细胞定位

[Isoform PDE9A1]: Cell projection, ruffle membrane