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PDE8B O95263

高亲和力cAMP特异性和IBMX不敏感3',5'-环磷酸二酯酶8B (HsPDE8B) (EC 3.1.4.53) (细胞增殖诱导基因22蛋白)

蛋白质信息 (UniProt)

高亲和力cAMP特异性和IBMX不敏感3',5'-环磷酸二酯酶8B (HsPDE8B) (EC 3.1.4.53) (细胞增殖诱导基因22蛋白)

O95263

功能描述

水解第二信使cAMP,cAMP是许多重要生理过程的关键调节因子。可能参与甲状腺中的特定信号传导。

组织特异性

Abundantly expressed in the thyroid. Also very weakly expressed in brain, spinal cord and placenta. In the thyroid isoform 1 predominates, and isoforms 2 and 6 are also highly expressed. In the placenta isoforms 1 and 2 are expressed equally. In the brain isoform 2 predominates.

关键词

Alternative splicing cAMP Cushing syndrome Disease variant Hydrolase Metal-binding Phosphoprotein Proteomics identification Reference proteome