双3',5'-环AMP和-GMP磷酸二酯酶11A (EC 3.1.4.35) (EC 3.1.4.53) (cAMP和cGMP磷酸二酯酶11A)
双3',5'-环AMP和-GMP磷酸二酯酶11A (EC 3.1.4.35) (EC 3.1.4.53) (cAMP和cGMP磷酸二酯酶11A)
Q9HCR9功能描述
通过调节细胞内环核苷酸cAMP和cGMP的浓度，在信号转导中发挥作用 (PubMed:10725373, PubMed:10906126, PubMed:11050148, PubMed:16330539)。分别催化cAMP和cGMP水解为5'-AMP和5'-GMP (PubMed:10725373, PubMed:10906126, PubMed:11050148)。 {ECO:0000269|PubMed:10725373, ECO:0000269|PubMed:10906126, ECO:0000269|PubMed:11050148, ECO:0000269|PubMed:16330539}。
组织特异性
Isoform 1 is present in prostate, pituitary, heart and liver. It is however not present in testis nor in penis, suggesting that weak inhibition by Tadalafil (Cialis) is not relevant (at protein level). Isoform 2 may be expressed in testis. Isoform 4 is expressed in adrenal cortex.
亚细胞定位
Cytoplasm, cytosol
关键词