PDE10A Q9Y233

cAMP和cAMP抑制的cGMP 3',5'-环磷酸二酯酶10A (EC 3.1.4.17)

蛋白质信息 (UniProt)

cAMP和cAMP抑制的cGMP 3',5'-环磷酸二酯酶10A (EC 3.1.4.17)

Q9Y233

功能描述

通过调节细胞内环核苷酸浓度在信号转导中发挥作用 (PubMed:10373451, PubMed:10393245, PubMed:16330539, PubMed:17389385, PubMed:27058447)。能够水解cAMP和cGMP，但对cAMP具有更高的亲和力，且以cAMP为底物时效率更高 (PubMed:10373451, PubMed:10393245, PubMed:17389385, PubMed:27058447)。可能在调节纹状体中的cAMP和cGMP水平方面发挥关键作用，纹状体是大脑中参与控制运动和认知的区域 (PubMed:27058447)。 {ECO:0000269|PubMed:10373451, ECO:0000269|PubMed:10393245, ECO:0000269|PubMed:16330539, ECO:0000269|PubMed:17389385, ECO:0000269|PubMed:27058447}。

组织特异性

Abundant in the putamen and caudate nucleus regions of brain and testis, moderately expressed in the thyroid gland, pituitary gland, thalamus and cerebellum.

亚细胞定位

Cytoplasm, cytosol

关键词

3D-structure Allosteric enzyme Alternative initiation Alternative splicing cAMP cAMP-binding cGMP cGMP-binding Cytoplasm Disease variant

外部链接

UniProt: Q9Y233

NCBI Gene

GeneCards