PCBP1 Q15365

聚(rC)结合蛋白1 (Alpha-CP1) (异质核核糖核蛋白E1) (hnRNP E1) (核酸结合蛋白SUB2.3)

蛋白质信息 (UniProt)

聚(rC)结合蛋白1 (Alpha-CP1) (异质核核糖核蛋白E1) (hnRNP E1) (核酸结合蛋白SUB2.3)

Q15365

功能描述

单链核酸结合蛋白，优先结合寡聚dC (PubMed:15731341, PubMed:7556077, PubMed:7607214, PubMed:8152927)。与PCBP2一起，为红细胞生成所必需，可能通过调节mRNA剪接 (By similarity)。 {ECO:0000250|UniProtKB:P60335, ECO:0000269|PubMed:15731341, ECO:0000269|PubMed:7556077, ECO:0000269|PubMed:7607214, ECO:0000269|PubMed:8152927}.; FUNCTION: (Microbial infection) 在脊髓灰质炎病毒感染的情况下，与病毒蛋白3CD协同在病毒RNA复制起始中发挥作用。 {ECO:0000269|PubMed:12414943}.

组织特异性

Abundantly expressed in skeletal muscle, thymus and peripheral blood leukocytes while a lower expression is observed in prostate, spleen, testis, ovary, small intestine, heart, liver, adrenal and thyroid glands.

亚细胞定位

Nucleus

关键词

3D-structure Acetylation Cytoplasm Direct protein sequencing DNA-binding Isopeptide bond Nucleus Phosphoprotein Proteomics identification Reference proteome

外部链接

UniProt: Q15365

NCBI Gene

GeneCards