PAWR Q96IZ0

PRKC凋亡WT1调节蛋白 (前列腺凋亡反应4蛋白) (Par-4)

功能描述

促凋亡蛋白，能够选择性地诱导癌细胞凋亡，敏化细胞对多种凋亡刺激的反应，并在动物模型中导致肿瘤消退。通过激活Fas促死亡通路并协同抑制NF-kappa-B转录活性，诱导特定癌细胞凋亡。抑制由WT1介导的转录激活并增强其介导的转录抑制。通过与WT1相互作用下调抗凋亡蛋白BCL2。其本身似乎也是一种转录抑制因子。可能直接参与调节BACE1的淀粉样前体蛋白(APP)剪切活性。 {ECO:0000269|PubMed:11585763}。

组织特异性

Widely expressed. Expression is elevated in various neurodegenerative diseases such as amyotrophic lateral sclerosis, Alzheimer, Parkinson and Huntington diseases and stroke. Down-regulated in several cancers.

亚细胞定位

Cytoplasm. Nucleus. Note=Mainly cytoplasmic in absence of apoptosis signal and in normal cells. Nuclear in most cancer cell lines. Nuclear entry seems to be essential but not sufficient for apoptosis (By similarity). Nuclear localization includes nucleoplasm and PML nuclear bodies.