PAPOLA P51003

聚(A)聚合酶α (PAP-alpha) (EC 2.7.7.19) (多核苷酸腺苷酰转移酶α)

蛋白质信息 (UniProt)

聚(A)聚合酶α (PAP-alpha) (EC 2.7.7.19) (多核苷酸腺苷酰转移酶α)

P51003

功能描述

聚合酶，用于创建mRNA的3'-poly(A)尾。在某些多聚腺苷酸化位点，也为核糖核酸内切裂解反应所必需。可能通过其C末端与裂解和多聚腺苷酸化特异性因子(CPSF)相互作用而获得特异性。 {ECO:0000269|PubMed:19224921}。

亚细胞定位

Cytoplasm. Nucleus. Note=The 90 kDa form is nuclear while the 100 kDa and the 106 kDa forms are both nuclear and cytoplasmic.

关键词

3D-structure Acetylation Alternative splicing ATP-binding Cytoplasm Isopeptide bond Magnesium Manganese Metal-binding mRNA processing

UniProt: P51003

NCBI Gene

GeneCards