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PANK2 Q9BZ23

线粒体泛酸激酶2 (hPanK2) (EC 2.7.1.33) (泛酸激酶2) [切割为:线粒体泛酸激酶2中间体形式 (iPanK2); 线粒体泛酸激酶2成熟形式 (mPanK2)]

蛋白质信息 (UniProt)

线粒体泛酸激酶2 (hPanK2) (EC 2.7.1.33) (泛酸激酶2) [切割为:线粒体泛酸激酶2中间体形式 (iPanK2); 线粒体泛酸激酶2成熟形式 (mPanK2)]

Q9BZ23

功能描述

[Isoform 1]: 线粒体亚型,催化泛酸磷酸化生成4'-磷酸泛酸,这是辅酶A (CoA) 合成的第一步也是限速步骤 (PubMed:15659606, PubMed:16272150, PubMed:17242360, PubMed:17825826)。脐静脉内皮细胞 (HUVEC) 的血管生成活性所必需 (PubMed:30221726)。 {ECO:0000269|PubMed:15659606, ECO:0000269|PubMed:16272150, ECO:0000269|PubMed:17242360, ECO:0000269|PubMed:17825826, ECO:0000269|PubMed:30221726}.; FUNCTION: [Isoform 4]: 细胞质亚型,催化泛酸磷酸化生成4'-磷酸泛酸,这是辅酶A (CoA) 合成的第一步也是限速步骤。 {ECO:0000269|PubMed:16272150}.

组织特异性

Expressed in the brain (at protein level) (PubMed:15659606, PubMed:17825826). Ubiquitous (PubMed:11479594). Highly expressed in the testis (PubMed:17825826). Expressed in the umbilical vein endothelial cells (HUVEC) (PubMed:30221726).

亚细胞定位

[Isoform 1]: Mitochondrion

关键词

3D-structure Alternative initiation Alternative splicing Angiogenesis ATP-binding Coenzyme A biosynthesis Cytoplasm Direct protein sequencing Disease variant Kinase