PAEP P09466

糖蛋白 (GD) (胎盘蛋白 14) (PP14) (妊娠相关子宫内膜α-2球蛋白) (PAEG) (PEG) (孕激素相关子宫内膜蛋白) (孕酮相关子宫内膜蛋白) (透明带结合抑制因子-1) (ZIF-1)

功能描述

调节受精过程中关键步骤并具有免疫调节作用的糖蛋白。在生殖组织中已鉴定出四种糖型，即glycodelin-S、-A、-F和-C，它们在糖基化和生物活性上有所不同。Glycodelin-A具有避孕和免疫抑制活性 (PubMed:7531163, PubMed:9918684)。Glycodelin-C刺激精子与透明带结合 (PubMed:17192260)。Glycodelin-F抑制精子-透明带结合，并显著抑制孕酮诱导的精子顶体反应 (PubMed:12672671)。精浆中的Glycodelin-S维持人类精子的未获能状态 (PubMed:15883155)。 {ECO:0000269|PubMed:12672671, ECO:0000269|PubMed:15883155, ECO:0000269|PubMed:17192260, ECO:0000269|PubMed:7531163, ECO:0000269|PubMed:9918684}。

组织特异性

This protein is, the main protein synthesized and secreted in the endometrium from mid-luteal phase of the menstrual cycle and during the first semester of pregnancy (PubMed:3667877). Glycodelin-A is expressed in amniotic fluid, endometrium/decidua and maternal serum (at protein level) (PubMed:3194393). Glycodelin-F is expressed in follicular fluid, luteinized granulosa cells and the oviduct (at protein level) (PubMed:12672671). Glycodelin-S is expressed in seminal plasma and seminal vesicles (at protein level) (PubMed:9239694). Glycodelin-C is detected in cumulus cells (at protein level), but cumulus cells do not synthesize Glycodelin-C but take up and convert glycodelin-A and -F vis glycan remodeling (PubMed:17192260).

亚细胞定位

Secreted