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P2RX2 Q9UBL9

P2X嘌呤受体2 (P2X2) (ATP受体) (嘌呤能受体)

蛋白质信息 (UniProt)

P2X嘌呤受体2 (P2X2) (ATP受体) (嘌呤能受体)

Q9UBL9

功能描述

ATP门控的非选择性跨膜阳离子通道,对钾、钠和钙具有通透性 (PubMed:10570044, PubMed:31636190)。细胞外ATP激活诱导多种细胞反应,如感觉神经元中的兴奋性突触后反应、神经肌肉接头 (NMJ) 形成、听觉、味觉感知和蠕动 (By similarity)。在内耳中,调节声音转导和听觉神经传递、外毛细胞电运动、内耳缝隙连接和K(+)循环 (PubMed:23345450)。介导神经元之间以及从神经元到平滑肌的突触传递 (By similarity)。 {ECO:0000250|UniProtKB:Q8K3P1, ECO:0000269|PubMed:10570044, ECO:0000269|PubMed:23345450, ECO:0000269|PubMed:31636190}。

组织特异性

Expressed in both the central and peripheral nervous system, as well as in the pituitary gland.

亚细胞定位

Cell membrane

关键词

Alternative splicing ATP-binding Cell membrane Deafness Disease variant Disulfide bond Glycoprotein Hearing Ion channel Ion transport