OSTN P61366

骨分泌蛋白 (肌肉分泌蛋白) [裂解为：加工骨分泌蛋白]

功能描述

激素，作为发育中大脑皮层树突生长的调节因子，响应感觉经验 (PubMed:27830782)。在脑部由膜去极化诱导，并抑制发育中皮层神经元的树突分支 (PubMed:27830782)。可能通过结合利钠肽受体 NPR3/NPR-C 起作用，从而阻止 NPR3/NPR-C 与利钠肽之间的结合，导致 cGMP 产生增加 (By similarity)。 {ECO:0000250|UniProtKB:P61364, ECO:0000269|PubMed:27830782}。

组织特异性

Enriched in neocortical regions of the developing cerebral cortex (PubMed:27830782). Not expressed in other compartments of the neocortical wall or in brain regions such as the hippocampus, striatum, mediodorsal nucleus of the thalamus and cerebellum (PubMed:27830782). Also expressed in bone (PubMed:14523025). In developing neonatal rib bone, present at high level in osteoblasts on bone-forming surfaces, in newly incorporated osteocytes and in some late hypertrophic chondrocytes (at protein level) (PubMed:15923362). In adult bone, localizes specifically to osteoblasts and young osteocytes at bone-forming sites (at protein level) (PubMed:15923362).

亚细胞定位

Secreted