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OPN1SW P03999

短波敏感视蛋白1 (蓝锥感光色素) (蓝敏感视蛋白) (BOP)

蛋白质信息 (UniProt)

短波敏感视蛋白1 (蓝锥感光色素) (蓝敏感视蛋白) (BOP)

P03999

功能描述

视色素是介导视觉的光吸收分子。它们由一个脱辅基蛋白,视蛋白,与顺式视黄醛共价连接组成 (Probable)。 ventral 视网膜中视锥细胞外段的组织维持所必需的,但对于功能性视锥感光细胞的维持并非必需 (By similarity)。参与确保视网膜膜蛋白的正确丰度和定位 (By similarity)。可能在弱光下增加光谱敏感性 (By similarity)。 {ECO:0000250|UniProtKB:P51491, ECO:0000305|PubMed:2937147}。

组织特异性

The three color pigments are found in the cone photoreceptor cells (PubMed:2937147). Expressed throughout the epidermis and dermis, primarily in the stratum granulosum in the facial and abdominal skin (at protein level) (PubMed:30168605). Expressed in dermal fibroblasts (at protein level) (PubMed:31380578). Expressed in melanocytes (at protein level) (PubMed:31730232).

亚细胞定位

Cell membrane

关键词

3D-structure Cell membrane Cell projection Chromophore Cytoplasm Disease variant Disulfide bond G-protein coupled receptor Glycoprotein Membrane