OLFM4 Q6UX06

嗅质蛋白-4 (OLM4) (抗凋亡蛋白GW112) (G-CSF刺激克隆1蛋白) (hGC-1) (hOLfD)

功能描述

可能通过促进S期向G2/M期的转换来促进胰腺癌细胞的增殖。在髓系白血病细胞系中，抑制细胞生长并诱导细胞分化和凋亡。可能参与抑制EIF4EBP1的磷酸化/失活。促进细胞粘附，很可能是通过与细胞表面凝集素和钙粘蛋白的相互作用。 {ECO:0000269|PubMed:16566923, ECO:0000269|PubMed:17270022, ECO:0000269|PubMed:20724538}。

组织特异性

Expressed during myeloid lineage development. Much higher expression in bone marrow neutrophils than in peripheral blood neutrophils (at protein level). Strongly expressed in the prostate, small intestine and colon and moderately expressed in the bone marrow and stomach. Overexpressed in some pancreatic cancer tissues.

亚细胞定位

Secreted, extracellular space. Mitochondrion. Note=Subcellular location is not clearly defined: has been shown to be secreted (PubMed:16566923), but also in the mitochondrion (PubMed:15059901, PubMed:20724538), cytoplasm and plasma membrane (PubMed:20724538) and in the nucleus (PubMed:15059901).