2-氧戊二酸脱氢酶样蛋白，线粒体 (EC 1.2.4.2) (2-氧戊二酸脱氢酶复合体组分E1样) (OGDC-E1样) (α-酮戊二酸脱氢酶样)
2-氧戊二酸脱氢酶样蛋白，线粒体 (EC 1.2.4.2) (2-氧戊二酸脱氢酶复合体组分E1样) (OGDC-E1样) (α-酮戊二酸脱氢酶样)
Q9ULD0功能描述
2-oxoglutarate dehydrogenase multienzyme complex (OGDHC)的2-oxoglutarate dehydrogenase (E1-like)组分，该复合体在三羧酸循环中介导alpha-ketoglutarate的脱羧。OGDHC复合体催化2-oxoglutarate转化为succinyl-CoA和CO(2)的全过程，同时将NAD(+)还原为NADH (By similarity)。OGDHC复合体主要在线粒体中具有活性 (By similarity)。参与细胞增殖的抑制和细胞凋亡 (PubMed:23152800, PubMed:31175094)。 {ECO:0000250|UniProtKB:D3ZQD3, ECO:0000269|PubMed:23152800, ECO:0000269|PubMed:31175094}。
组织特异性
Expressed in the brain and the liver.
亚细胞定位
Mitochondrion matrix
关键词