NVL O15381

含缬酪肽样核蛋白 (NVLp) (核VCP样蛋白)

蛋白质信息 (UniProt)

含缬酪肽样核蛋白 (NVLp) (核VCP样蛋白)

O15381

功能描述

通过与TERT相互作用参与端粒酶全酶的组装并影响端粒酶活性 (PubMed:22226966)。参与pre-rRNA加工途径的早期和晚期阶段 (PubMed:26166824)。在核仁中时空调节60S核糖体亚基的生物发生 (PubMed:15469983, PubMed:16782053, PubMed:26456651, PubMed:29107693)。通过ATPase活性催化特定组装因子（如WDR74）从pre-60S核糖体颗粒上释放 (PubMed:26456651, PubMed:28416111, PubMed:29107693)。 {ECO:0000269|PubMed:15469983, ECO:0000269|PubMed:16782053, ECO:0000269|PubMed:22226966, ECO:0000269|PubMed:26166824, ECO:0000269|PubMed:26456651, ECO:0000269|PubMed:28416111, ECO:0000269|PubMed:29107693}。

组织特异性

Widely expressed. Highest level of expression in heart, placenta, skeletal muscle, pancreas and retina.

亚细胞定位

[Isoform 2]: Nucleus, nucleoplasm

关键词

3D-structure Acetylation Alternative splicing ATP-binding Isopeptide bond Nucleotide-binding Nucleus Phosphoprotein Proteomics identification Reference proteome

外部链接

UniProt: O15381

NCBI Gene

GeneCards