NUDT1 P36639

氧化嘌呤核苷三磷酸水解酶 (EC 3.6.1.56) (2-羟基-dATP二磷酸酶) (7,8-二氢-8-氧鸟苷三磷酸酶) (8-氧-dGTP酶) (甲基化嘌呤核苷三磷酸水解酶) (EC 3.6.1.-) (核苷二磷酸连接部分X基序1) (Nudix基序1)

功能描述

氧化嘌呤核苷三磷酸水解酶，是氧化核苷酸库的重要清除剂 (PubMed:10608900, PubMed:12857738, PubMed:22556419, PubMed:24695224, PubMed:24695225, PubMed:26238318, PubMed:28679043, PubMed:7713500, PubMed:8226881)。催化2-oxo-dATP (2-hydroxy-dATP) 水解为2-oxo-dAMP (PubMed:10373420)。对2-oxo-ATP、8-oxo-dGTP和8-oxo-dATP也具有显著的水解酶活性 (PubMed:10373420, PubMed:11139615)。通过水解氧化嘌呤核苷三磷酸，防止其掺入DNA以及随后的A:T到C:G和G:C到T:A的颠换 (PubMed:10373420, PubMed:10608900, PubMed:11756418, PubMed:12857738, PubMed:16607562, PubMed:24695224, PubMed:24695225, PubMed:26999531, PubMed:28035004, PubMed:8226881)。也催化甲基化嘌呤核苷三磷酸的水解，防止其整合入DNA (PubMed:30304478, PubMed:32144205)。通过这种抗诱变活性保护细胞免受氧化应激 (PubMed:10608900, PubMed:12857738, PubMed:24695224, PubMed:24695225, PubMed:30304478, PubMed:32144205, PubMed:7713500, PubMed:8226881)。 {ECO:0000269|PubMed:10373420, ECO:0000269|PubMed:10608900, ECO:0000269|PubMed:11139615, ECO:0000269|PubMed:11756418, ECO:0000269|PubMed:12857738, ECO:0000269|PubMed:16607562, ECO:0000269|PubMed:22556419, ECO:0000269|PubMed:24695224, ECO:0000269|PubMed:24695225, ECO:0000269|PubMed:26238318, ECO:0000269|PubMed:26999531, ECO:0000269|PubMed:28035004, ECO:0000269|PubMed:28679043, ECO:0000269|PubMed:30304478, ECO:0000269|PubMed:32144205, ECO:0000269|PubMed:7713500, ECO:0000269|PubMed:8226881}。

组织特异性

Widely expressed with highest expression in thymus, testis, embryo and proliferating blood lymphocytes.

亚细胞定位

[Isoform p18]: Cytoplasm, cytosol