NUB1 Q9Y5A7

NEDD8终极破坏因子1 (类泛素蛋白负调节因子1) (肾癌抗原NY-REN-18)

蛋白质信息 (UniProt)

NEDD8终极破坏因子1 (类泛素蛋白负调节因子1) (肾癌抗原NY-REN-18)

Q9Y5A7

功能描述

NEDD8结合系统的特异性下调因子。招募NEDD8、UBD及其结合物至蛋白酶体进行降解。Isoform 1比isoform 2更有效地促进NEDD8的降解。{ECO:0000269|PubMed:16707496}。

组织特异性

Widely expressed with lowest expression in the pancreas for isoform 1 and in leukocytes, liver, prostate and skeletal muscle for isoform 2.

亚细胞定位

Nucleus

关键词

3D-structure Alternative splicing Coiled coil Nucleus Proteomics identification Reference proteome Repeat

UniProt: Q9Y5A7

NCBI Gene

GeneCards