NSUN5 Q96P11

28S rRNA (胞嘧啶-C(5))-甲基转移酶 (EC 2.1.1.-) (NOL1相关蛋白) (NOL1R) (NOL1/NOP2/Sun结构域家族成员5) (Williams-Beuren综合征染色体区域20A蛋白)

蛋白质信息 (UniProt)

28S rRNA (胞嘧啶-C(5))-甲基转移酶 (EC 2.1.1.-) (NOL1相关蛋白) (NOL1R) (NOL1/NOP2/Sun结构域家族成员5) (Williams-Beuren综合征染色体区域20A蛋白)

Q96P11

功能描述

S-adenosyl-L-methionine依赖性甲基转移酶，特异性甲基化28S rRNA中胞嘧啶3782位（m5C3782）的C(5)位置 (PubMed:23913415, PubMed:31428936, PubMed:31722427)。m5C3782促进蛋白质翻译，而不影响核糖体生物发生和保真度 (PubMed:31428936, PubMed:31722427)。为胼胝体和大脑皮层发育所必需 (By similarity)。 {ECO:0000250|UniProtKB:Q8K4F6, ECO:0000269|PubMed:23913415, ECO:0000269|PubMed:31428936, ECO:0000269|PubMed:31722427}。

组织特异性

Ubiquitous (PubMed:11978965, PubMed:12073013). Detected in placenta, heart and skeletal muscle (PubMed:11978965, PubMed:12073013).

亚细胞定位

Nucleus, nucleolus

关键词

3D-structure Acetylation Alternative splicing Direct protein sequencing Methyltransferase Nucleus Phosphoprotein Proteomics identification Reference proteome RNA-binding

外部链接

UniProt: Q96P11

NCBI Gene

GeneCards