NRP1 O14786

神经纤毛蛋白-1 (血管内皮细胞生长因子165受体) (CD抗原 CD304)

功能描述

参与心血管系统发育、血管生成、特定神经元回路形成以及神经系统外器官发生的细胞表面受体。介导信号素的化学排斥活性 (PubMed:10688880, PubMed:9288753, PubMed:9529250)。识别其配体上的C端规则 (CendR) 基序 R/KXXR/K，导致细胞内化和血管渗漏 (PubMed:19805273)。结合信号素3A、PGF的PLGF-2同工型、VEGFA的VEGF165同工型和VEGFB (PubMed:10688880, PubMed:19805273, PubMed:9288753, PubMed:9529250)。与KDR共表达可增加VEGF165与KDR的结合以及趋化性。调节VEGF诱导的血管生成。与VEGFA结合启动运动神经元轴突导向和细胞体迁移所需的信号通路，包括胚胎发育期间面运动神经元从菱脑节4到菱脑节6的尾侧迁移 (By similarity)。通过与ABCB8/MITOSUR相互作用调节线粒体铁转运 (PubMed:30623799)。 {ECO:0000250|UniProtKB:P97333, ECO:0000269|PubMed:10688880, ECO:0000269|PubMed:19805273, ECO:0000269|PubMed:30623799, ECO:0000269|PubMed:9288753, ECO:0000269|PubMed:9529250}.; FUNCTION: (Microbial infection) 作为人冠状病毒SARS-CoV-2感染的宿主因子。识别并结合SARS-CoV-2刺突蛋白S1上的CendR基序RRAR，从而增强SARS-CoV-2感染。 {ECO:0000269|PubMed:33082293, ECO:0000269|PubMed:33082294}.; FUNCTION: [Isoform 2]: 结合VEGF-165并可能抑制其与细胞的结合 (PubMed:10748121, PubMed:26503042)。可能通过隔离VEGF-165诱导细胞凋亡 (PubMed:10748121)。也可能结合信号素家族的各种成员。其表达对血管数量和完整性有不利影响。 {ECO:0000269|PubMed:10748121, ECO:0000269|PubMed:26503042}.

组织特异性

[Isoform 1]: The expression of isoforms 1 and 2 does not seem to overlap. Expressed in olfactory epithelium (at protein level) (PubMed:33082293). Expressed in fibroblasts (at protein level) (PubMed:36213313). Expressed by the blood vessels of different tissues. In the developing embryo it is found predominantly in the nervous system. In adult tissues, it is highly expressed in heart and placenta; moderately in lung, liver, skeletal muscle, kidney and pancreas; and low in adult brain (PubMed:10688880, PubMed:9529250). Expressed in the central nervous system, including olfactory related regions such as the olfactory tubercles and paraolfactory gyri (PubMed:33082293).

亚细胞定位

[Isoform 2]: Secreted