NRG3 P56975

膜结合型神经调节蛋白-3前体 (Pro-NRG3) [切割产生：神经调节蛋白-3 (NRG-3)]

功能描述

ERBB4酪氨酸激酶受体的直接配体。结合导致配体刺激的酪氨酸磷酸化和受体的激活。不结合EGF受体、ERBB2或ERBB3受体。可能是少突胶质细胞的存活因子。 {ECO:0000269|PubMed:16478787, ECO:0000269|PubMed:9275162}。

组织特异性

Highly expressed in most regions of the brain with the exception of corpus callosum. Expressed at lower level in testis. Not detected in heart, placenta, lung, liver, skeletal muscle, kidney, pancreas, spleen, thymus, prostate, ovary, small intestine, colon and peripheral blood leukocytes.

亚细胞定位

[Pro-neuregulin-3, membrane-bound isoform]: Cell membrane