NPW Q8N729

神经肽W (前体蛋白L8) (hPPL8) [切割为：神经肽W-23 (NPW23) (hL8); 神经肽W-30 (NPW30) (hL8C)]

功能描述

在组织进入垂体前叶的神经内分泌信号中发挥调节作用。刺激饮水和摄食。可能在下丘脑对压力的反应中发挥作用 (By similarity)。NPW23 激活 GPR7 和 GPR8 的效率高于 NPW30。 {ECO:0000250}。

组织特异性

Detected in cerebrospinal fluid and urine (at protein level) (PubMed:25326458, PubMed:36213313, PubMed:37453717). Detected at high levels in the substantia nigra, fetal kidney and trachea; at lower levels in testis, uterus, ovary and placenta. Not detectable in many regions of the central nervous system. Also detected at high levels in lymphoblastic leukemia and colorectal adenocarcinoma.

亚细胞定位

Secreted