NPPC P23582

C型利钠肽 [切割为：CNP-22; CNP-29; CNP-53]

蛋白质信息 (UniProt)

C型利钠肽 [切割为：CNP-22; CNP-29; CNP-53]

P23582

功能描述

[CNP-22]: 激素，通过调节软骨生长板软骨细胞的增殖和分化在软骨内骨化中发挥作用 (By similarity)。可能也具有血管活性和利钠作用 (PubMed:1672777)。通过特异性结合并刺激 NPR2 产生 cGMP 发挥作用 (PubMed:1672777, PubMed:21098034)。结合清除受体 NPR3 (PubMed:11533490)。 {ECO:0000250|UniProtKB:Q61839, ECO:0000269|PubMed:11533490, ECO:0000269|PubMed:1672777, ECO:0000269|PubMed:21098034}。

组织特异性

[CNP-22]: In the kidney, predominantly expressed in the distal tubular cells (at protein level).

亚细胞定位

Secreted.

关键词

3D-structure Cleavage on pair of basic residues Direct protein sequencing Disulfide bond Hormone Osteogenesis Pharmaceutical Proteomics identification Reference proteome Secreted

外部链接

UniProt: P23582

NCBI Gene

GeneCards