NOTCH4 Q99466

神经源性位点Notch同源蛋白4 (Notch 4) (hNotch4) [切割产生：Notch 4胞外截短；Notch 4胞内结构域]

功能描述

作为膜结合配体Jagged1、Jagged2和Delta1的受体发挥作用，以调节细胞命运决定。在通过释放的notch胞内结构域(NICD)进行配体激活后，它与RBPJ/RBPSUH形成转录激活复合物，并激活enhancer of split位点的基因。影响分化、增殖和凋亡程序的执行。可能调节发育中血管系统的分支形态发生（根据相似性）。{ECO:0000250}。

组织特异性

Highly expressed in the heart, moderately in the lung and placenta and at low levels in the liver, skeletal muscle, kidney, pancreas, spleen, lymph node, thymus, bone marrow and fetal liver. No expression was seen in adult brain or peripheral blood leukocytes.

亚细胞定位

Cell membrane; Single-pass type I membrane protein.; SUBCELLULAR LOCATION: [Notch 4 intracellular domain]: Nucleus. Note=Following proteolytical processing NICD is translocated to the nucleus.