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NOS3 P29474

一氧化氮合酶 3 (EC 1.14.13.39) (组成型 NOS) (cNOS) (EC-NOS) (NOS III型) (NOSIII) (一氧化氮合酶,内皮) (内皮 NOS) (eNOS)

蛋白质信息 (UniProt)

一氧化氮合酶 3 (EC 1.14.13.39) (组成型 NOS) (cNOS) (EC-NOS) (NOS III型) (NOSIII) (一氧化氮合酶,内皮) (内皮 NOS) (eNOS)

P29474

功能描述

产生一氧化氮 (NO),其通过cGMP介导的信号转导通路参与血管平滑肌舒张 (PubMed:1378832)。NO介导冠状血管中血管内皮生长因子 (VEGF) 诱导的血管生成,并通过激活血小板促进血液凝固。 {ECO:0000269|PubMed:1378832}.; FUNCTION: [Isoform eNOS13C]: 缺乏eNOS活性,是一种显性负性形式,可能通过与isoform 1形成异二聚体下调eNOS活性。

组织特异性

Platelets, placenta, liver and kidney.

亚细胞定位

Cell membrane. Membrane, caveola. Cytoplasm, cytoskeleton. Golgi apparatus. Note=Specifically associates with actin cytoskeleton in the G2 phase of the cell cycle; which is favored by interaction with NOSIP and results in a reduced enzymatic activity.

关键词

3D-structure Alternative splicing Calcium Calmodulin-binding Cell membrane Cytoplasm Cytoskeleton Direct protein sequencing FAD Flavoprotein