NLRC4 Q9NPP4

含CARD结构域NLR家族蛋白4 (CARD、LRR和NACHT包含蛋白) (CED-4样蛋白族) (含半胱天冬酶招募结构域蛋白12) (Ice蛋白酶激活因子) (Ipaf)

功能描述

炎症小体的关键组分，间接感知来自致病细菌和真菌的特定蛋白，并通过组装炎症小体复合物作出反应，促进caspase-1激活、细胞因子产生和巨噬细胞焦亡 (PubMed:15107016)。NLRC4炎症小体作为针对一系列胞内细菌的先天免疫反应的一部分被激活 (By similarity)。 {ECO:0000250|UniProtKB:Q3UP24, ECO:0000269|PubMed:15107016}。

组织特异性

Isoform 2 is expressed ubiquitously, although highly expressed in lung and spleen. Isoform 1 is highly expressed in lung, followed by leukocytes especially monocytes, lymph node, colon, brain, prostate, placenta, spleen, bone marrow and fetal liver. Isoform 4 is only detected in brain.

亚细胞定位

Cytoplasm