NFATC1 O95644

活化T细胞核因子，细胞质1 (NF-ATc1) (NFATc1) (NFAT转录复合体细胞质组分) (NF-ATc) (NFATc)

功能描述

在T细胞中细胞因子基因的诱导性表达中发挥作用，特别是在IL-2或IL-4基因转录的诱导中。也控制胚胎心肌细胞中的基因表达。可能不仅调节T淋巴细胞的活化和增殖，还调节其分化及程序性死亡，以及淋巴样和非淋巴样细胞(PubMed:10358178)。破骨细胞发生所必需，并调节许多对破骨细胞分化和功能重要的基因(By similarity)。 {ECO:0000250|UniProtKB:O88942, ECO:0000269|PubMed:10358178}。

组织特异性

Expressed in thymus, peripheral leukocytes as T-cells and spleen. Isoforms A are preferentially expressed in effector T-cells (thymus and peripheral leukocytes) whereas isoforms B and isoforms C are preferentially expressed in naive T-cells (spleen). Isoforms B are expressed in naive T-cells after first antigen exposure and isoforms A are expressed in effector T-cells after second antigen exposure. Isoforms IA are widely expressed but not detected in liver nor pancreas, neural expression is strongest in corpus callosum. Isoforms IB are expressed mostly in muscle, cerebellum, placenta and thymus, neural expression in fetal and adult brain, strongest in corpus callosum.

亚细胞定位

Cytoplasm