NENF Q9UMX5

Neudesin (细胞永生化相关蛋白 2) (神经元源性神经营养因子) (蛋白 GIG47) (功能未知分泌蛋白) (SPUF 蛋白)

功能描述

在出生后成熟神经元中作为神经营养因子，增强神经元存活 (PubMed:31536960)。在胚胎阶段未分化的神经祖细胞中促进细胞增殖和神经发生，并抑制星形胶质细胞的分化 (By similarity)。其神经营养活性通过 MAPK1/ERK2、MAPK3/ERK1 和 AKT1/AKT 通路发挥 (By similarity)。与血红素结合可增强神经营养活性 (By similarity)。还作为厌食性神经营养因子，有助于能量平衡 (By similarity)。 {ECO:0000250|UniProtKB:Q9CQ45, ECO:0000269|PubMed:31536960}。

组织特异性

Ubiquitously expressed with high expression in heart. Over-expressed in various tumors including carcinomas of the uterine cervix, lymphoma, colon, lung, skin and leukemia, as well as carcinoma of the breast.

亚细胞定位

Secreted, extracellular space