NELFE P18615

负延伸因子E (NELF-E) (RNA结合蛋白RD)

蛋白质信息 (UniProt)

负延伸因子E (NELF-E) (RNA结合蛋白RD)

P18615

功能描述

NELF复合物的必需组分，该复合物负调控RNA聚合酶II的转录延伸 (PubMed:10199401, PubMed:27256882)。NELF复合物通过与DSIF复合物结合发挥作用并引起转录暂停，其作用被P-TEFb激酶复合物拮抗 (PubMed:11940650, PubMed:12612062, PubMed:27256882)。提供NELF复合物中最强的RNA结合活性，可能最初将NELF复合物募集到RNA (PubMed:18303858, PubMed:27256882, PubMed:27282391)。 {ECO:0000269|PubMed:10199401, ECO:0000269|PubMed:11940650, ECO:0000269|PubMed:12612062, ECO:0000269|PubMed:18303858, ECO:0000269|PubMed:27256882, ECO:0000269|PubMed:27282391}.; FUNCTION: (Microbial infection) NELF复合物参与HIV-1潜伏期，可能涉及将PCF11募集到暂停的RNA聚合酶II。 {ECO:0000269|PubMed:23884411}.

组织特异性

Widely expressed. Expressed in heart, brain, lung, placenta, liver, skeletal muscle, kidney and pancreas.

亚细胞定位

Nucleus

关键词

3D-structure ADP-ribosylation Alternative splicing Chromosome Coiled coil Direct protein sequencing Isopeptide bond Nucleus Phosphoprotein Proteomics identification

外部链接

UniProt: P18615

NCBI Gene

GeneCards