NADPH依赖性双黄素氧化还原酶1 (EC 1.18.1.-) (NADPH依赖性含FMN和FAD氧化还原酶) (新型还原酶1)
NADPH依赖性双黄素氧化还原酶1 (EC 1.18.1.-) (NADPH依赖性含FMN和FAD氧化还原酶) (新型还原酶1)
Q9UHB4功能描述
依赖NADPH的还原酶，是细胞质铁硫(Fe-S)蛋白组装(CIA)机制的核心组分 (PubMed:10625700, PubMed:15900210, PubMed:20802492, PubMed:23596212, PubMed:28648056)。通过其FAD和FMN辅基将电子从NADPH转移至CIAPIN1的[2Fe-2S]簇，CIAPIN1是CIA机制的另一个关键组分 (PubMed:20802492, PubMed:23596212, PubMed:28648056)。进而，该还原态簇为细胞质铁硫簇蛋白的组装提供电子 (PubMed:20802492, PubMed:23596212)。它还可以还原CISD1的[2Fe-2S]簇并激活该参与Fe/S簇修复的蛋白 (PubMed:28648056)。在体外，可在可溶性细胞色素b5/CYB5A存在下完全激活甲硫氨酸合酶/MTR (PubMed:12871938)。 {ECO:0000255|HAMAP-Rule:MF_03178, ECO:0000269|PubMed:10625700, ECO:0000269|PubMed:12871938, ECO:0000269|PubMed:15900210, ECO:0000269|PubMed:20802492, ECO:0000269|PubMed:23596212, ECO:0000269|PubMed:28648056}。
组织特异性
Low expression in brain, heart, kidney, pancreas, prostate and skeletal muscle. Highest levels in the placenta. Expressed in cancer cell lines including promyelocytic leukemia, HeLaS3, chronic myelagenous leukemia, lymphoblastic leukemia, Burkitt's lymphoma, colorectal adenocarcinoma, lung carcinoma, and melanoma G-361.
亚细胞定位
Cytoplasm, perinuclear region
关键词