NDN Q99608

坏死蛋白

功能描述

生长抑制因子，促进细胞进入细胞周期停滞。功能上类似于视网膜母细胞瘤蛋白，它结合并抑制细胞周期促进蛋白的活性，例如SV40大T抗原、腺病毒E1A和转录因子E2F。Necdin还与p53相互作用并以叠加方式抑制细胞生长。还作为转录因子发挥作用，直接结合特定的富含鸟嘌呤的DNA序列（根据相似性）。 {ECO:0000250}。

组织特异性

Almost ubiquitous. Detected in fetal brain, lung, liver and kidney; in adult heart, brain, placenta, lung, liver, skeletal muscle, kidney, pancreas, spleen, thymus, prostate, testis, ovary, small intestine and colon. Not detected in peripheral blood leukocytes. In brain, restricted to post-mitotic neurons.

亚细胞定位

Perikaryon. Nucleus. Note=Neural perikarya, translocates to the nucleus of postmitotic neurons and interacts with the nuclear matrix.