NCAPG Q9BPX3

凝缩蛋白复合体亚基3（染色体相关蛋白G）（凝缩蛋白亚基CAP-G）（hCAP-G）（黑色素瘤抗原NY-MEL-3）（非SMC凝缩蛋白I复合体亚基G）（XCAP-G同源物）

功能描述

Condensin复合物的调节亚基，该复合物是将间期染色质转化为有丝分裂样凝集染色体所必需的。在I型拓扑异构酶存在下，Condensin复合物可能将正超螺旋引入松弛DNA中，并在II型拓扑异构酶存在下将切口DNA转化为正结形式。 {ECO:0000269|PubMed:11136719}。

组织特异性

Highly expressed in testis.

亚细胞定位

Nucleus. Cytoplasm. Chromosome. Note=In interphase cells, the majority of the condensin complex is found in the cytoplasm, while a minority of the complex is associated with chromatin. A subpopulation of the complex however remains associated with chromosome foci in interphase cells. During mitosis, most of the condensin complex is associated with the chromatin. At the onset of prophase, the regulatory subunits of the complex are phosphorylated by CDK1, leading to condensin's association with chromosome arms and to chromosome condensation. Dissociation from chromosomes is observed in late telophase.